A colloidal drug delivery system (CDDS) based on a novel surface modification process help to reserve the constraining activity of surfaces is described. Aquasome a nanoparticle submicronic structure (diameter below 1 µm) made up with carbohydrates. They received much attention to develop a drug delivery system as an alternative to liposome technology in order to overcome the problems related to the stability of these vesicles in biological fluids. Aquasome a molecular carrier, consist of ceramic core (colloidal precipitation) to which glassy carbohydrates are then allowed to adsorb as a nanometer thick surface coating, is formed, which is then absorbed with pharmaceuticals. The carbohydrate coating functions as a dehydroprotectant and stabilizes subsequently non-covalently bound immobilized members of biochemically reactive surface members such as pharmaceuticals. Many of the physical properties of this enabling system have been characterized in vitro and in animal models. It has got a quite versatile application potential as a carrier for delivery of vaccines, haemoglobin, drugs, dyes, enzymes and even genetic material.
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